November 21, 2023
Dr. Eckman and Dr. Pacheco-Quinto describe their research on Aβ42 fibrillization in synaptic endosomes in the Journal of Neuroscience
Drs. Eckman and Pacheco-Quinto share their latest research findings in a new article in the Journal of Neuroscience, titled: Nascent Aβ42 fibrillization in synaptic endosomes precedes plaque formation in a mouse model of Alzheimer’s like β-amyloidosis. Their findings provide evidence that Aβ aggregates building up in synapses are formed locally, within synaptic endosomes, due to disruptions […] Read more »
January 31, 2023
The Legacy of Angels Foundation awards research grant to Dr. Chris Lee
Dr. Chris Lee recently received funding from the The Legacy of Angels Foundation to continue his important research characterizing and profiling the genetic variants that cause Krabbe disease, and evaluating therapeutics that may improve outcomes for Krabbe disease patients. Dr. Lee’s research lab has been leading discoveries in Krabbe disease research for many years. Most […] Read more »
March 10, 2022
Dr. Memon, Dr. Griffin and Dr. Lee collaborate to study Bile Acid Metabolism in Neonates
Infants born prematurely often receive parenteral nutrition (PN), a life-saving source of nutrition delivered intravenously. However, data has shown that infants fed PN long-term may be predisposed to parenteral nutrition-associated liver disease (PNALD); in part, due to alterations in bile acid metabolism. These studies are ongoing, and are aimed at better understanding the connection between PN […] Read more »
August 22, 2021
Improving Diagnosis and Treatment for Patients with Lyme Neuroborreliosis
Dr. Eckman, in collaboration with Dr. John Halperin, lead a research team studying cerebrospinal fluid markers of Lyme disease, including Lyme neuroborreliosis, the nervous system infection associated with Lyme disease that occurs in approximately 10-15% of patients. Their recent work was published in the journal Clinical Infectious Disease. Read more »
December 01, 2020
Dr. Eckman and Dr. Javier Pacheco-Quinto present at AHS Research Day
Drs. Eckman and Pacheco-Quinto present their most recent research, titled, Intravesicular retention of amyloid beta aggregates precedes plaque formation in TgCRND8 APP transgenic mice, at AHS Research Day. The study presented was part of their ongoing collaboration to understand protein homeostasis in Alzheimer’s disease, such as how intracellular proteases regulate multiple, distinct pools of beta-amyloid (Aβ) […] Read more »