Javier Pacheco-Quinto, PhD

Assistant Professor of Biomedical Sciences

Bio

Dr. Pacheco-Quinto’s research is focused on understanding the risk factors and pathogenesis of Alzheimer’s disease (AD), and identifying novel therapeutics to treat the disease. He is particularly interested in describing the early events in AD progression that lead to the abnormal and toxic accumulation of beta amyloid (Aβ) in the brains of AD patients. In his previous studies he has described how vascular risk factors such as hypercholesterolemia, hyperhomocysteinemia and hypertension alter the production and removal of Aβ, and how ischemic insults impact the initiation of AD and other neurological conditions. His current work at BRInj is focused on understanding the role of the endothelin system in AD development. Specifically, he is studying how endothelin-converting enzymes (ECEs) regulate brain Aβ levels, and determining whether alterations in the endothelin system may impact Aβ catabolism. He remains active in research to define how ischemic insults contribute to the development of neurodegenerative disease, both during aging or early development; and is developing and testing compounds to treat ischemic related neurodevelopmental disorders.

Education

PhD, Neuroscience, Louisiana State University Health Sciences Center
BA, Clinical Biology, Universitat de Barcelona, Barcelona, Spain

Publications

View on pubmed.org >

Experience

Postdoctoral Training, Neuroscience, Louisiana State University Health Sciences Center